3UBY

Crystal structure of human alklyadenine DNA glycosylase in a lower and higher-affinity complex with DNA

Summary for 3UBY

• Entry DOI: 10.2210/pdb3uby/pdb
• Related: 1BNK 1EWN 1F4R 1F6O 3QI5
• Descriptor: DNA-3-methyladenine glycosylase, DNA (5'-D(*GP*AP*CP*AP*TP*GP*(EDC)P*TP*TP*GP*CP*CP*T)-3') (3 entities in total)
• Functional Keywords: alkyladenine dna glycosylase fold, aag, dna repair, dna binding, nucleus, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (Potential): P29372
• Total number of polymer chains: 4
• Total formula weight: 56562.97

Authors

Setser, J.W.,Lingaraju, G.M.,Davis, C.A.,Samson, L.D.,Drennan, C.L. (deposition date: 2011-10-25, release date: 2011-12-28, Last modification date: 2023-09-13)

• Primary citation: Setser, J.W.,Lingaraju, G.M.,Davis, C.A.,Samson, L.D.,Drennan, C.L.; Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.; Biochemistry, 51:382-390, 2012; PubMed: 22148158; DOI: 10.1021/bi201484k

Experimental method

X-RAY DIFFRACTION (2 Å)