3UAS

Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene

Summary for 3UAS

Entry DOI	10.2210/pdb3uas/pdb
Descriptor	Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, phenanthren-9-ylacetaldehyde, ... (6 entities in total)
Functional Keywords	p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains	1
Total formula weight	55826.84
Authors	Gay, S.C.,Zhang, H.,Shah, M.B.,Stout, C.D.,Halpert, J.R.,Hollenberg, P.F. (deposition date: 2011-10-21, release date: 2013-01-09, Last modification date: 2023-09-13)
Primary citation	Zhang, H.,Gay, S.C.,Shah, M.,Foroozesh, M.,Liu, J.,Osawa, Y.,Zhang, Q.,Stout, C.D.,Halpert, J.R.,Hollenberg, P.F. Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis. Biochemistry, 52:355-364, 2013 Cited by PubMed: 23276288 DOI: 10.1021/bi301567z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.939 Å)

Structure validation