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3U8W

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor

Summary for 3U8W
Entry DOI10.2210/pdb3u8w/pdb
Related1YQJ 3DS6 3DT1 3GFE 3ITZ 3LHJ
DescriptorMitogen-activated protein kinase 14, 3-[3-(2-chloro-6-fluorophenyl)-5-ethyl-6-oxo-5,6-dihydro[1,2,4]triazolo[4,3-b]pyridazin-7-yl]-N-cyclopropyl-4-methylbenzamide (3 entities in total)
Functional Keywordsserine/threonine protein kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q16539
Total number of polymer chains1
Total formula weight42464.85
Authors
Mohr, C.,Jordan, S. (deposition date: 2011-10-17, release date: 2012-08-29, Last modification date: 2024-02-28)
Primary citationHerberich, B.,Jackson, C.,Wurz, R.P.,Pettus, L.H.,Sherman, L.,Liu, Q.,Henkle, B.,Saris, C.J.,Wong, L.M.,Chmait, S.,Lee, M.R.,Mohr, C.,Hsieh, F.,Tasker, A.S.
Identification of triazolopyridazinones as potent p38alpha inhibitors.
Bioorg.Med.Chem.Lett., 22:1226-1229, 2012
Cited by
PubMed: 22196117
DOI: 10.1016/j.bmcl.2011.11.067
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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