3U3Z

Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142

Summary for 3U3Z

• Entry DOI: 10.2210/pdb3u3z/pdb
• Descriptor: Microcephalin, Histone H2A.X peptide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: dna repair, cell cycle regulation, cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, centrosome: Q8NEM0
• Total number of polymer chains: 2
• Total formula weight: 22819.21

Authors

Singh, N.,Thompson, J.R.,Heroux, A.,Mer, G. (deposition date: 2011-10-06, release date: 2012-07-25, Last modification date: 2023-12-06)

• Primary citation: Singh, N.,Basnet, H.,Wiltshire, T.D.,Mohammad, D.H.,Thompson, J.R.,Heroux, A.,Botuyan, M.V.,Yaffe, M.B.,Couch, F.J.,Rosenfeld, M.G.,Mer, G.; Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.; Proc.Natl.Acad.Sci.USA, 109:14381-14386, 2012; PubMed: 22908299; DOI: 10.1073/pnas.1212366109

Experimental method

X-RAY DIFFRACTION (1.5 Å)