3TZB
Quinone Oxidoreductase (NQ02) bound to NSC13000
Summary for 3TZB
Entry DOI | 10.2210/pdb3tzb/pdb |
Descriptor | Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, fad |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P16083 |
Total number of polymer chains | 4 |
Total formula weight | 107594.41 |
Authors | Dunstan, M.S.,Leys, D. (deposition date: 2011-09-27, release date: 2011-11-02, Last modification date: 2024-02-28) |
Primary citation | Nolan, K.A.,Dunstan, M.S.,Caraher, M.C.,Scott, K.A.,Leys, D.,Stratford, I.J. In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-kappa B signaling. Mol.Cancer Ther., 11:194-203, 2012 Cited by PubMed: 22090421DOI: 10.1158/1535-7163.MCT-11-0543 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1901 Å) |
Structure validation
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