3TYG

Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3)

Summary for 3TYG

• Entry DOI: 10.2210/pdb3tyg/pdb
• Related: 3TV3 3TWC
• Descriptor: Envelope glycoprotein gp160, PGT128 light chain, Ig lambda-2 chain C regions, PGT128 heavy chain, Ig gamma-1 chain C region, ... (5 entities in total)
• Functional Keywords: gp120, hiv-1, env, fab, hiv-1 neutralizing antibody, immune system, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 72745.36

Authors

Pejchal, R.,Huang, P.S.,Schief, W.R.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2011-09-25, release date: 2011-10-19, Last modification date: 2023-09-13)

• Primary citation: Pejchal, R.,Doores, K.J.,Walker, L.M.,Khayat, R.,Huang, P.S.,Wang, S.K.,Stanfield, R.L.,Julien, J.P.,Ramos, A.,Crispin, M.,Depetris, R.,Katpally, U.,Marozsan, A.,Cupo, A.,Maloveste, S.,Liu, Y.,McBride, R.,Ito, Y.,Sanders, R.W.,Ogohara, C.,Paulson, J.C.,Feizi, T.,Scanlan, C.N.,Wong, C.H.,Moore, J.P.,Olson, W.C.,Ward, A.B.,Poignard, P.,Schief, W.R.,Burton, D.R.,Wilson, I.A.; A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.; Science, 334:1097-1103, 2011; PubMed: 21998254; DOI: 10.1126/science.1213256

Experimental method

X-RAY DIFFRACTION (3.25 Å)