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3TUD

Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide

Summary for 3TUD
Entry DOI10.2210/pdb3tud/pdb
Related3TUB 3TUC
DescriptorTyrosine-protein kinase SYK, N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide (3 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane (Probable): P43405
Total number of polymer chains1
Total formula weight35410.48
Authors
Lovering, F.,McDonald, J.,Whitlock, G.,Glossop, P.,Phillips, C.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarenson, A. (deposition date: 2011-09-16, release date: 2012-08-29, Last modification date: 2024-02-28)
Primary citationLovering, F.,McDonald, J.,Whitlock, G.A.,Glossop, P.A.,Phillips, C.,Bent, A.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarensen, A.
Identification of Type-II Inhibitors Using Kinase Structures.
Chem.Biol.Drug Des., 80:657-664, 2012
Cited by
PubMed: 22759374
DOI: 10.1111/j.1747-0285.2012.01443.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.33 Å)
Structure validation

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