3TUD
Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide
Summary for 3TUD
Entry DOI | 10.2210/pdb3tud/pdb |
Related | 3TUB 3TUC |
Descriptor | Tyrosine-protein kinase SYK, N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane (Probable): P43405 |
Total number of polymer chains | 1 |
Total formula weight | 35410.48 |
Authors | Lovering, F.,McDonald, J.,Whitlock, G.,Glossop, P.,Phillips, C.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarenson, A. (deposition date: 2011-09-16, release date: 2012-08-29, Last modification date: 2024-02-28) |
Primary citation | Lovering, F.,McDonald, J.,Whitlock, G.A.,Glossop, P.A.,Phillips, C.,Bent, A.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarensen, A. Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80:657-664, 2012 Cited by PubMed: 22759374DOI: 10.1111/j.1747-0285.2012.01443.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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