3TUC

Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Summary for 3TUC

Entry DOI	10.2210/pdb3tuc/pdb
Related	3TUB 3TUD
Descriptor	Tyrosine-protein kinase SYK, 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane (Probable): P43405
Total number of polymer chains	1
Total formula weight	35389.49
Authors	Lovering, F.,McDonald, J.,Whitlock, G.,Glossop, P.,Phillips, C.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarenson, A. (deposition date: 2011-09-16, release date: 2012-08-29, Last modification date: 2024-02-28)
Primary citation	Lovering, F.,McDonald, J.,Whitlock, G.A.,Glossop, P.A.,Phillips, C.,Bent, A.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarensen, A. Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80:657-664, 2012 Cited by PubMed: 22759374 DOI: 10.1111/j.1747-0285.2012.01443.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation