3TUB

Crystal structure of SYK kinase domain with 1-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-3-((1R,2S)-2-phenylcyclopropyl)urea

Summary for 3TUB

• Entry DOI: 10.2210/pdb3tub/pdb
• Related: 3TUC 3TUD
• Descriptor: Tyrosine-protein kinase SYK, 1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1R,2S)-2-phenylcyclopropyl]urea (3 entities in total)
• Functional Keywords: kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane (Probable): P43405
• Total number of polymer chains: 1
• Total formula weight: 34508.60

Authors

Han, S. (deposition date: 2011-09-16, release date: 2012-08-29, Last modification date: 2024-02-28)

• Primary citation: Lovering, F.,McDonald, J.,Whitlock, G.A.,Glossop, P.A.,Phillips, C.,Bent, A.,Sabnis, Y.,Ryan, M.,Fitz, L.,Lee, J.,Chang, J.S.,Han, S.,Kurumbail, R.,Thorarensen, A.; Identification of Type-II Inhibitors Using Kinase Structures.; Chem.Biol.Drug Des., 80:657-664, 2012; PubMed: 22759374; DOI: 10.1111/j.1747-0285.2012.01443.x

Experimental method

X-RAY DIFFRACTION (2.23 Å)