3TU9

Crystal structure of rabbit muscle aldolase bound with 5-O-methyl mannitol 1,6-phosphate

Summary for 3TU9

Entry DOI	10.2210/pdb3tu9/pdb
Descriptor	Fructose-bisphosphate aldolase A, 2-O-methyl-1,6-di-O-phosphono-D-mannitol (3 entities in total)
Functional Keywords	beta-barrel, mammalian aldolase, mannitol-bisphosphate, trypanosomal aldolase, inhibitor docking, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Oryctolagus cuniculus (rabbit)
Cellular location	Cytoplasm, myofibril, sarcomere, I band : P00883
Total number of polymer chains	4
Total formula weight	158479.32
Authors	Arthus-Cartier, G.,Sygusch, J. (deposition date: 2011-09-16, release date: 2011-10-12, Last modification date: 2023-09-13)
Primary citation	Mabiala-Bassiloua, C.G.,Arthus-Cartier, G.,Hannaert, V.,Therisod, H.,Sygusch, J.,Therisod, M. Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases. ACS Med Chem Lett, 2:804-808, 2011 Cited by PubMed: 24900268 DOI: 10.1021/ml200129s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation