3TS8
Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element
Summary for 3TS8
| Entry DOI | 10.2210/pdb3ts8/pdb |
| Descriptor | Cellular tumor antigen p53, CDKN1A(p21) sense strand, CDKN1A(p21) anti-sense strand, ... (5 entities in total) |
| Functional Keywords | beta sandwich, multidomain, oligomerization, tp53, p53, tumor suppressor, tetramer, dna binding, antitumor protein-dna complex, antitumor protein/dna |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
| Total number of polymer chains | 6 |
| Total formula weight | 122707.37 |
| Authors | Halazonetis, T.D.,Emamzadah, S. (deposition date: 2011-09-12, release date: 2011-11-23, Last modification date: 2024-02-28) |
| Primary citation | Emamzadah, S.,Tropia, L.,Halazonetis, T.D. Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element. Mol Cancer Res, 9:1493-1499, 2011 Cited by PubMed: 21933903DOI: 10.1158/1541-7786.MCR-11-0351 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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