3TJD

co-crystal structure of Jak2 with thienopyridine 19

Summary for 3TJD

Entry DOI	10.2210/pdb3tjd/pdb
Related	3TJC
Descriptor	Tyrosine-protein kinase JAK2, 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide (3 entities in total)
Functional Keywords	jak2, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein (By similarity): O60674
Total number of polymer chains	2
Total formula weight	71084.81
Authors	Huang, X. (deposition date: 2011-08-24, release date: 2011-11-30, Last modification date: 2011-12-28)
Primary citation	Schenkel, L.B.,Huang, X.,Cheng, A.,Deak, H.L.,Doherty, E.,Emkey, R.,Gu, Y.,Gunaydin, H.,Kim, J.L.,Lee, J.,Loberg, R.,Olivieri, P.,Pistillo, J.,Tang, J.,Wan, Q.,Wang, H.L.,Wang, S.W.,Wells, M.C.,Wu, B.,Yu, V.,Liu, L.,Geuns-Meyer, S. Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54:8440-8450, 2011 Cited by PubMed: 22087750 DOI: 10.1021/jm200911r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation