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3TJC

Co-crystal structure of jak2 with thienopyridine 8

Summary for 3TJC
Entry DOI10.2210/pdb3tjc/pdb
DescriptorTyrosine-protein kinase JAK2, 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide (3 entities in total)
Functional Keywordsjak2, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndomembrane system; Peripheral membrane protein (By similarity): O60674
Total number of polymer chains2
Total formula weight70984.65
Authors
Huang, X. (deposition date: 2011-08-24, release date: 2011-11-30, Last modification date: 2011-12-28)
Primary citationSchenkel, L.B.,Huang, X.,Cheng, A.,Deak, H.L.,Doherty, E.,Emkey, R.,Gu, Y.,Gunaydin, H.,Kim, J.L.,Lee, J.,Loberg, R.,Olivieri, P.,Pistillo, J.,Tang, J.,Wan, Q.,Wang, H.L.,Wang, S.W.,Wells, M.C.,Wu, B.,Yu, V.,Liu, L.,Geuns-Meyer, S.
Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors.
J.Med.Chem., 54:8440-8450, 2011
Cited by
PubMed: 22087750
DOI: 10.1021/jm200911r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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