3TH5

Crystal structure of wild-type RAC1

Summary for 3TH5

• Entry DOI: 10.2210/pdb3th5/pdb
• Related: 3SBD 3SBE 4GZL 4GZM
• Descriptor: Ras-related C3 botulinum toxin substrate 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: rossmann fold, gtpase, gtp binding, protein binding, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000
• Total number of polymer chains: 2
• Total formula weight: 46561.08

Authors

Ha, B.H.,Boggon, T.J. (deposition date: 2011-08-18, release date: 2012-07-18, Last modification date: 2023-09-13)

• Primary citation: Krauthammer, M.,Kong, Y.,Ha, B.H.,Evans, P.,Bacchiocchi, A.,McCusker, J.P.,Cheng, E.,Davis, M.J.,Goh, G.,Choi, M.,Ariyan, S.,Narayan, D.,Dutton-Regester, K.,Capatana, A.,Holman, E.C.,Bosenberg, M.,Sznol, M.,Kluger, H.M.,Brash, D.E.,Stern, D.F.,Materin, M.A.,Lo, R.S.,Mane, S.,Ma, S.,Kidd, K.K.,Hayward, N.K.,Lifton, R.P.,Schlessinger, J.,Boggon, T.J.,Halaban, R.; Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.; Nat.Genet., 44:1006-1014, 2012; PubMed: 22842228; DOI: 10.1038/ng.2359

Experimental method

X-RAY DIFFRACTION (2.3 Å)