3TCT
Structure of wild-type TTR in complex with tafamidis
Summary for 3TCT
| Entry DOI | 10.2210/pdb3tct/pdb |
| Related | 2QGC 2QGD 2QGE |
| Descriptor | Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid (3 entities in total) |
| Functional Keywords | amyloid, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, secreted, thyroid hormone, transport, kinetic stabilizer, inhibition of the amyloid cascade, binding protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28170.95 |
| Authors | Connelly, S.,Kelly, J.W.,Wilson, I.A. (deposition date: 2011-08-09, release date: 2012-05-30, Last modification date: 2023-09-13) |
| Primary citation | Bulawa, C.E.,Connelly, S.,Devit, M.,Wang, L.,Weigel, C.,Fleming, J.A.,Packman, J.,Powers, E.T.,Wiseman, R.L.,Foss, T.R.,Wilson, I.A.,Kelly, J.W.,Labaudiniere, R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc.Natl.Acad.Sci.USA, 109:9629-9634, 2012 Cited by PubMed: 22645360DOI: 10.1073/pnas.1121005109 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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