3TC5

Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives

Summary for 3TC5

Entry DOI	10.2210/pdb3tc5/pdb
Related	1PIN 2ITK 2Q5A 2ZR6
Descriptor	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, (11alpha,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate, HEXAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	pin1 mutant (r14a), oncogenic transformation, small molecule, cell cycle, rotamase, phosphoprotein, nucleus, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q13526
Total number of polymer chains	1
Total formula weight	19222.24
Authors	Graeber, M.,Janczyk, W.,Sperl, B.,Elumalai, N.,Kozany, C.,Hausch, F.,Holak, T.A.,Berg, T. (deposition date: 2011-08-08, release date: 2011-08-31, Last modification date: 2023-09-13)
Primary citation	Graber, M.,Janczyk, W.,Sperl, B.,Elumalai, N.,Kozany, C.,Hausch, F.,Holak, T.A.,Berg, T. Selective targeting of disease-relevant protein binding domains by o-phosphorylated natural product derivatives. Acs Chem.Biol., 6:1008-1014, 2011 Cited by PubMed: 21797253 DOI: 10.1021/cb2001796 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation