3T5U

Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide

Summary for 3T5U

Entry DOI	10.2210/pdb3t5u/pdb
Related	1CA2 2WEJ 3T5Z
Descriptor	Carbonic anhydrase 2, ZINC ION, N-hydroxybenzenesulfonamide, ... (6 entities in total)
Functional Keywords	protein-inhibitor complex, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30329.83
Authors	Di Fiore, A.,Maresca, A.,Alterio, V.,Supuran, C.T.,De Simone, G. (deposition date: 2011-07-28, release date: 2012-06-20, Last modification date: 2023-09-13)
Primary citation	Di Fiore, A.,Maresca, A.,Alterio, V.,Supuran, C.T.,De Simone, G. Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II. Chem.Commun.(Camb.), 47:11636-11638, 2011 Cited by PubMed: 21952494 DOI: 10.1039/c1cc14575d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation