3T2N

Human hepsin protease in complex with the Fab fragment of an inhibitory antibody

Summary for 3T2N

Entry DOI	10.2210/pdb3t2n/pdb
Related	1O5E 1P57 1Z8G
Descriptor	Serine protease hepsin, Antibody, Fab fragment, Heavy Chain, Antibody, Fab fragment, Light Chain, ... (4 entities in total)
Functional Keywords	type ii transmembrane serine protease, srcr domain, substrates include pro-hepsin, pro-hgf, laminin-332, transmembrane, hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type II membrane protein: P05981
Total number of polymer chains	6
Total formula weight	174682.21
Authors	Koschubs, T.,Dengl, S.,Duerr, H.,Kaluza, K.,Georges, G.,Hartl, C.,Jennewein, S.,Lanzendoerfer, M.,Auer, J.,Stern, A.,Huang, K.-S.,Kostrewa, D.,Ries, S.,Hansen, S.,Kohnert, U.,Cramer, P.,Mundigl, O. (deposition date: 2011-07-22, release date: 2011-12-28, Last modification date: 2012-07-25)
Primary citation	Koschubs, T.,Dengl, S.,Durr, H.,Kaluza, K.,Georges, G.,Hartl, C.,Jennewein, S.,Lanzendorfer, M.,Auer, J.,Stern, A.,Huang, K.S.,Packman, K.,Gubler, U.,Kostrewa, D.,Ries, S.,Hansen, S.,Kohnert, U.,Cramer, P.,Mundigl, O. Allosteric antibody inhibition of human hepsin protease. Biochem.J., 442:483-494, 2012 Cited by PubMed: 22132769 DOI: 10.1042/BJ20111317 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation