3SVV
Crystal Structure of T338C c-Src covalently bound to vinylsulfonamide-pyrazolopyrimidine 9
Summary for 3SVV
| Entry DOI | 10.2210/pdb3svv/pdb |
| Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-(3-{[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl}phenyl)ethanesulfonamide (3 entities in total) |
| Functional Keywords | covalently bound ligand, cysteine gatekeeper, src, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Gallus gallus (bantam,chickens) |
| Cellular location | Cell membrane (By similarity): P00523 |
| Total number of polymer chains | 2 |
| Total formula weight | 66206.29 |
| Authors | Garske, A.L.,Peters, U.,Cortesi, A.,Perez, J.,Shokat, K.M. (deposition date: 2011-07-12, release date: 2011-08-17, Last modification date: 2024-03-13) |
| Primary citation | Garske, A.L.,Peters, U.,Cortesi, A.T.,Perez, J.L.,Shokat, K.M. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc.Natl.Acad.Sci.USA, 108:15046-15052, 2011 Cited by PubMed: 21852571DOI: 10.1073/pnas.1111239108 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.204 Å) |
Structure validation
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