3SPF
Crystal Structure of Bcl-xL bound to BM501
Summary for 3SPF
Entry DOI | 10.2210/pdb3spf/pdb |
Related | 3SP7 |
Descriptor | Bcl-2-like protein 1, 4-(4-chlorophenyl)-1-[(3S)-3,4-dihydroxybutyl]-N-[3-(4-methylpiperazin-1-yl)propyl]-3-phenyl-1H-pyrrole-2-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | bcl-2-like protein, apoptosis-apoptosis inhibitor complex, apoptosis regulator-inhibitor complex, apoptosis regulator/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 1 |
Total formula weight | 20570.04 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2011-07-01, release date: 2012-06-27, Last modification date: 2024-02-28) |
Primary citation | Zhou, H.,Chen, J.,Meagher, J.L.,Yang, C.Y.,Aguilar, A.,Liu, L.,Bai, L.,Cong, X.,Cai, Q.,Fang, X.,Stuckey, J.A.,Wang, S. Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. J.Med.Chem., 55:4664-4682, 2012 Cited by PubMed: 22448988DOI: 10.1021/jm300178u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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