3SHC

Human Thrombin In Complex With UBTHR101

Summary for 3SHC

Entry DOI	10.2210/pdb3shc/pdb
Related	3P17 3QTO 3QTV 3QWC 3QX5 3RLW
Related PRD ID	PRD_000788
Descriptor	Thrombin light chain, Thrombin heavy chain, Hirudin variant-2, ... (7 entities in total)
Functional Keywords	serine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, thrombin inhibitor, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	36193.50
Authors	Biela, A.,Heine, A.,Klebe, G. (deposition date: 2011-06-16, release date: 2012-06-20, Last modification date: 2023-12-06)
Primary citation	Biela, A.,Khayat, M.,Tan, H.,Kong, J.,Heine, A.,Hangauer, D.,Klebe, G. Impact of ligand and protein desolvation on ligand binding to the S1 pocket of thrombin J.Mol.Biol., 418:350-366, 2012 Cited by PubMed: 22366545 DOI: 10.1016/j.jmb.2012.01.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation