3SFH

Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor

Summary for 3SFH

• Entry DOI: 10.2210/pdb3sfh/pdb
• Related: 3SFF
• Descriptor: Histone deacetylase 8, POTASSIUM ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9BY41
• Total number of polymer chains: 1
• Total formula weight: 42545.52

Authors

Stams, T.,Vash, B. (deposition date: 2011-06-13, release date: 2011-07-20, Last modification date: 2024-02-28)

• Primary citation: Whitehead, L.,Dobler, M.R.,Radetich, B.,Zhu, Y.,Atadja, P.W.,Claiborne, T.,Grob, J.E.,McRiner, A.,Pancost, M.R.,Patnaik, A.,Shao, W.,Shultz, M.,Tichkule, R.,Tommasi, R.A.,Vash, B.,Wang, P.,Stams, T.; Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.; Bioorg.Med.Chem., 19:4626-4634, 2011; PubMed: 21723733; DOI: 10.1016/j.bmc.2011.06.030

Experimental method

X-RAY DIFFRACTION (2.7 Å)