3SFF
Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor
Summary for 3SFF
Entry DOI | 10.2210/pdb3sff/pdb |
Related | 3SFH |
Descriptor | Histone deacetylase 8, (2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | deacetylase, nvp-lci785, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9BY41 |
Total number of polymer chains | 1 |
Total formula weight | 42441.00 |
Authors | |
Primary citation | Whitehead, L.,Dobler, M.R.,Radetich, B.,Zhu, Y.,Atadja, P.W.,Claiborne, T.,Grob, J.E.,McRiner, A.,Pancost, M.R.,Patnaik, A.,Shao, W.,Shultz, M.,Tichkule, R.,Tommasi, R.A.,Vash, B.,Wang, P.,Stams, T. Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg.Med.Chem., 19:4626-4634, 2011 Cited by PubMed: 21723733DOI: 10.1016/j.bmc.2011.06.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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