3S7D

Structural Basis of Substrate Methylation and Inhibition of SMYD2

Summary for 3S7D

• Entry DOI: 10.2210/pdb3s7d/pdb
• Related: 3S7B 3S7F 3S7J
• Descriptor: N-lysine methyltransferase SMYD2, Monomethylated p53 peptide, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total)
• Functional Keywords: methyltransferase, p53, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol (By similarity): Q9NRG4
• Total number of polymer chains: 2
• Total formula weight: 52074.72

Authors

Ferguson, A.D. (deposition date: 2011-05-26, release date: 2011-08-10, Last modification date: 2011-09-21)

• Primary citation: Ferguson, A.D.,Larsen, N.A.,Howard, T.,Pollard, H.,Green, I.,Grande, C.,Cheung, T.,Garcia-Arenas, R.,Cowen, S.,Wu, J.,Godin, R.,Chen, H.,Keen, N.; Structural Basis of Substrate Methylation and Inhibition of SMYD2.; Structure, 19:1262-1273, 2011; PubMed: 21782458; DOI: 10.1016/j.str.2011.06.011

Experimental method

X-RAY DIFFRACTION (2.3 Å)