3S3G

Crystal Structure of Human Aldose Reductase Complexed with Tolmetin

Summary for 3S3G

• Entry DOI: 10.2210/pdb3s3g/pdb
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Tolmetin, ... (4 entities in total)
• Functional Keywords: human aldose reductase, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 39070.38

Authors

Zheng, X.,Chen, J.,Luo, H.,Hu, X. (deposition date: 2011-05-18, release date: 2012-04-04, Last modification date: 2023-11-01)

• Primary citation: Zheng, X.,Zhang, L.,Zhai, J.,Chen, Y.,Luo, H.,Hu, X.; The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.; Febs Lett., 586:55-59, 2012; PubMed: 22155003; DOI: 10.1016/j.febslet.2011.11.023

Experimental method

X-RAY DIFFRACTION (1.8 Å)