3RZF

Crystal Structure of Inhibitor of kappaB kinase beta (I4122)

Replaces:  3QAD

Summary for 3RZF

• Entry DOI: 10.2210/pdb3rzf/pdb
• Related: 3QA8
• Descriptor: MGC80376 protein, (4-{[4-(4-chlorophenyl)pyrimidin-2-yl]amino}phenyl)[4-(2-hydroxyethyl)piperazin-1-yl]methanone (2 entities in total)
• Functional Keywords: kinase uld, kinase ubiquitin-like domain scaffold helix, kinase, i kappa b alpha, phosphorylation, immune system, signaling protein
• Biological source: Xenopus laevis (clawed frog,common platanna,platanna)
• Total number of polymer chains: 1
• Total formula weight: 78439.43

Authors

Xu, G.,Lo, Y.C.,Li, Q.,Napolitano, G.,Wu, X.,Jiang, X.,Dreano, M.,Karin, M.,Wu, H. (deposition date: 2011-05-11, release date: 2011-05-25, Last modification date: 2024-02-28)

• Primary citation: Xu, G.,Lo, Y.C.,Li, Q.,Napolitano, G.,Wu, X.,Jiang, X.,Dreano, M.,Karin, M.,Wu, H.; Crystal structure of inhibitor of KappaB kinase Beta.; Nature, 472:325-330, 2011; PubMed: 21423167; DOI: 10.1038/nature09853

Experimental method

X-RAY DIFFRACTION (4 Å)