3RYX

Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase

Summary for 3RYX

Entry DOI	10.2210/pdb3ryx/pdb
Related	3RYJ 3RYV 3RYY 3RYZ 3RZ0 3RZ1 3RZ5 3RZ7 3RZ8
Descriptor	Carbonic anhydrase 2, ZINC ION, N-(2,2,3,3,3-pentafluoropropyl)-4-sulfamoylbenzamide, ... (4 entities in total)
Functional Keywords	alpha beta, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29555.52
Authors	Snyder, P.W.,Bai, S.,Heroux, A.,Whitesides, G.W. (deposition date: 2011-05-11, release date: 2011-08-10, Last modification date: 2024-02-28)
Primary citation	Mecinovic, J.,Snyder, P.W.,Mirica, K.A.,Bai, S.,Mack, E.T.,Kwant, R.L.,Moustakas, D.T.,Heroux, A.,Whitesides, G.M. Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase. J.Am.Chem.Soc., 133:14017-14026, 2011 Cited by PubMed: 21790183 DOI: 10.1021/ja2045293 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation