3RUT

FXR with SRC1 and GSK359

Summary for 3RUT

Entry DOI	10.2210/pdb3rut/pdb
Related	3RUU 3RVF
Descriptor	Bile acid receptor, Nuclear receptor coactivator 1, SULFATE ION, ... (5 entities in total)
Functional Keywords	nuclear receptor, alpha-helical sandwich, transcription factor, rxr, transcription co-factors, bile acid, farnesoid, transcription regulator
Biological source	Homo sapiens (human) More
Cellular location	Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1 Nucleus : Q15788
Total number of polymer chains	2
Total formula weight	28950.00
Authors	Williams, S.P.,Madauss, K.P. (deposition date: 2011-05-05, release date: 2011-09-21, Last modification date: 2024-02-28)
Primary citation	Akwabi-Ameyaw, A.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,Miller, A.B.,Navas, F.,Parks, D.J.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B. Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21:6154-6160, 2011 Cited by PubMed: 21890356 DOI: 10.1016/j.bmcl.2011.08.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation