3RQ7

Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor

Summary for 3RQ7

Entry DOI	10.2210/pdb3rq7/pdb
Related	1Q4K 1UMW 3BZI 3C5L 3FVH 3HIK
Related PRD ID	PRD_000794
Descriptor	Serine/threonine-protein kinase PLK1, C6H5(CH2)8-derivatized peptide inhibitor (3 entities in total)
Functional Keywords	phosphopeptide binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P53350
Total number of polymer chains	2
Total formula weight	28131.10
Authors	Liu, F.,Park, J.-E.,Qian, W.-J.,Lim, D.C.,Graber, M.,Berg, T.,Yaffe, M.B.,Lee, K.S.,Burke Jr., T.R. (deposition date: 2011-04-27, release date: 2011-07-20, Last modification date: 2012-12-12)
Primary citation	Liu, F.,Park, J.E.,Qian, W.J.,Lim, D.,Graber, M.,Berg, T.,Yaffe, M.B.,Lee, K.S.,Burke, T.R. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat.Chem.Biol., 7:595-601, 2011 Cited by PubMed: 21765407 DOI: 10.1038/nchembio.614 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation