Summary for 3RJW
| Entry DOI | 10.2210/pdb3rjw/pdb |
| Descriptor | Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total) |
| Functional Keywords | chemical probe, methyltransferase inhibitor, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus : Q96KQ7 |
| Total number of polymer chains | 2 |
| Total formula weight | 67521.39 |
| Authors | Dong, A.,Wasney, G.A.,Tempel, W.,Liu, F.,Barsyte, D.,Allali-Hassani, A.,Chen, X.,Chau, I.,Hajian, T.,Senisterra, G.,Chavda, N.,Arora, K.,Siarheyeva, A.,Kireev, D.B.,Herold, J.M.,Bochkarev, A.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Frye, S.V.,Arrowsmith, C.H.,Brown, P.J.,Jin, J.,Vedadi, M.,Structural Genomics Consortium (SGC) (deposition date: 2011-04-15, release date: 2011-05-04, Last modification date: 2023-09-13) |
| Primary citation | Vedadi, M.,Barsyte-Lovejoy, D.,Liu, F.,Rival-Gervier, S.,Allali-Hassani, A.,Labrie, V.,Wigle, T.J.,Dimaggio, P.A.,Wasney, G.A.,Siarheyeva, A.,Dong, A.,Tempel, W.,Wang, S.C.,Chen, X.,Chau, I.,Mangano, T.J.,Huang, X.P.,Simpson, C.D.,Pattenden, S.G.,Norris, J.L.,Kireev, D.B.,Tripathy, A.,Edwards, A.,Roth, B.L.,Janzen, W.P.,Garcia, B.A.,Petronis, A.,Ellis, J.,Brown, P.J.,Frye, S.V.,Arrowsmith, C.H.,Jin, J. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat.Chem.Biol., 7:566-574, 2011 Cited by PubMed: 21743462DOI: 10.1038/nchembio.599 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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