3RIN

p38 kinase crystal structure in complex with small molecule inhibitor

Summary for 3RIN

Entry DOI	10.2210/pdb3rin/pdb
Descriptor	Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-indol]-6'-yl)benzamide (3 entities in total)
Functional Keywords	p38 map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	41703.64
Authors	Segarra, V.,Eastwood, P.,Roca, R.,Fisher, M.,Lamers, M. (deposition date: 2011-04-14, release date: 2012-02-29, Last modification date: 2023-09-13)
Primary citation	Eastwood, P.,Gonzalez, J.,Gomez, E.,Vidal, B.,Caturla, F.,Roca, R.,Balague, C.,Orellana, A.,Dominguez, M. Indolin-2-one p38(alpha) inhibitors I: design, profiling and crystallographic binding mode. Bioorg.Med.Chem.Lett., 21:4130-4133, 2011 Cited by PubMed: 21696951 DOI: 10.1016/j.bmcl.2011.05.114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation