3RIL

The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease

Summary for 3RIL

• Entry DOI: 10.2210/pdb3ril/pdb
• Related: 3RIK
• Descriptor: Glucosylceramidase, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: tim-barrel, lysosomal hydrolase, hydrolase, glycosylation, lysosome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 227556.46

Authors

Orwig, S.D.,Lieberman, R.L. (deposition date: 2011-04-13, release date: 2012-03-14, Last modification date: 2020-07-29)

• Primary citation: Orwig, S.D.,Tan, Y.L.,Grimster, N.P.,Yu, Z.,Powers, E.T.,Kelly, J.W.,Lieberman, R.L.; Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease; Biochemistry, 50:10647-10657, 2011; PubMed: 22047104; DOI: 10.1021/bi201619z

Experimental method

X-RAY DIFFRACTION (2.4 Å)