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3RHK

Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197

Summary for 3RHK
Entry DOI10.2210/pdb3rhk/pdb
DescriptorHepatocyte growth factor receptor, 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium (3 entities in total)
Functional Keywordskinase, receptor tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P08581
Total number of polymer chains2
Total formula weight72714.05
Authors
Eathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C. (deposition date: 2011-04-11, release date: 2011-04-27, Last modification date: 2024-02-21)
Primary citationEathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C.
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.
J.Biol.Chem., 286:20666-20676, 2011
Cited by
PubMed: 21454604
DOI: 10.1074/jbc.M110.213801
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.94 Å)
Structure validation

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