3RAE

Quinolone(Levofloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae

Summary for 3RAE

• Entry DOI: 10.2210/pdb3rae/pdb
• Related: 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAF
• Descriptor: DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, 5'-D(*CP*AP*TP*GP*AP*AP*T)-3', ... (9 entities in total)
• Functional Keywords: protein-dna cleavage complex, topoisomerase iia, levofloxacin, isomerase-dna-antibiotic complex, isomerase/dna/antibiotic
• Biological source: Streptococcus pneumoniae; More
• Cellular location: Cell membrane ; Peripheral membrane protein : P72525
• Total number of polymer chains: 8
• Total formula weight: 185552.11

Authors

Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,McAuley, K.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2011-03-28, release date: 2012-04-25, Last modification date: 2023-11-01)

• Primary citation: Veselkov, D.A.,Laponogov, I.,Pan, X.S.,Selvarajah, J.,Skamrova, G.B.,Branstrom, A.,Narasimhan, J.,Prasad, J.V.,Fisher, L.M.,Sanderson, M.R.; Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.; Acta Crystallogr.,Sect.D, 72:488-496, 2016; PubMed: 27050128; DOI: 10.1107/S2059798316001212

Experimental method

X-RAY DIFFRACTION (2.9 Å)