3RAD

Quinolone(Clinafloxacin)-DNA cleavage complex of type IV topoisomerase from S. pneumoniae

Summary for 3RAD

• Entry DOI: 10.2210/pdb3rad/pdb
• Related: 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAE 3RAF
• Descriptor: DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, 5'-D(*CP*AP*TP*GP*AP*AP*T)-3', ... (9 entities in total)
• Functional Keywords: protein-dna cleavage complex, topoisomerase iia, clinafloxacin, isomerase-dna-antibiotic complex, isomerase/dna/antibiotic
• Biological source: Streptococcus pneumoniae; More
• Total number of polymer chains: 8
• Total formula weight: 185560.94

Authors

Laponogov, I.,Pan, X.-S.,Veselkov, D.A.,McAuley, K.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2011-03-28, release date: 2012-04-25, Last modification date: 2018-10-03)

• Primary citation: Laponogov, I.,Pan, X.S.,Veselkov, D.A.,Cirz, R.T.,Wagman, A.,Moser, H.E.,Fisher, L.M.,Sanderson, M.R.; Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.; Open Biol, 6:-, 2016; PubMed: 27655731; DOI: 10.1098/rsob.160157

Experimental method

X-RAY DIFFRACTION (3.35 Å)