3R8G
AKR1C3 complex with ibuprofen
Summary for 3R8G
| Entry DOI | 10.2210/pdb3r8g/pdb |
| Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid, ... (5 entities in total) |
| Functional Keywords | tim barrel, ibuprofen, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P42330 |
| Total number of polymer chains | 1 |
| Total formula weight | 38989.13 |
| Authors | Yosaatmadja, Y.,Teague, R.M.,Flanagan, J.U.,Squire, C.J. (deposition date: 2011-03-24, release date: 2012-05-02, Last modification date: 2023-09-13) |
| Primary citation | Flanagan, J.U.,Yosaatmadja, Y.,Teague, R.M.,Chai, M.Z.,Turnbull, A.P.,Squire, C.J. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. Plos One, 7:e43965-e43965, 2012 Cited by PubMed: 22937138DOI: 10.1371/journal.pone.0043965 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.799 Å) |
Structure validation
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