3R8D

Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721

Summary for 3R8D

Entry DOI	10.2210/pdb3r8d/pdb
Descriptor	Nuclear receptor subfamily 1 group I member 2, 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE (3 entities in total)
Functional Keywords	nuclear receptor, pxr, xenobiotic, ligand binding domain, transcription regulation, xenobiotics, endobiotics, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O75469
Total number of polymer chains	1
Total formula weight	36587.64
Authors	Cheng, Y.,Redinbo, M.R. (deposition date: 2011-03-23, release date: 2011-08-17, Last modification date: 2024-02-21)
Primary citation	Cheng, Y.,Redinbo, M.R. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci., 20:1713-1719, 2011 Cited by PubMed: 21805522 DOI: 10.1002/pro.706 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation