3R4T

Crystal structure of 4-aminobutyrate aminotransferase GabT from Mycobacterium marinum covalently bound to pyridoxal phosphate

Summary for 3R4T

• Entry DOI: 10.2210/pdb3r4t/pdb
• Related: 3OKS 3Q8N
• Descriptor: 4-aminobutyrate aminotransferase GabT, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: structural genomics, seattle structural genomics center for infectious disease, ssgcid, mycobacterium, tuberculosis, smegmatis, marinum, water contaminant, pyridoxal phosphate, plp, llp, gamma amino butyric acid, gaba, gaba transferase, gabaculine, phenelzine, aminooxyacetic acid, phenylethylidenehydrazine, vigabatrin, valproic acid, transferase
• Biological source: Mycobacterium marinum
• Total number of polymer chains: 1
• Total formula weight: 50042.39

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2011-03-17, release date: 2011-03-30, Last modification date: 2023-12-06)

• Primary citation: Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J.; Increasing the structural coverage of tuberculosis drug targets.; Tuberculosis (Edinb), 95:142-148, 2015; PubMed: 25613812; DOI: 10.1016/j.tube.2014.12.003

Experimental method

X-RAY DIFFRACTION (2.5 Å)