3QSB

Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile

Summary for 3QSB

• Entry DOI: 10.2210/pdb3qsb/pdb
• Related: 1MMI 2POL
• Descriptor: DNA polymerase III subunit beta, (1R,5R)-5-{(1Z)-N-[(4'-fluorobiphenyl-4-yl)methoxy]butanimidoyl}-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile, ... (4 entities in total)
• Functional Keywords: dna replication, sliding clamp, dnan, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Escherichia coli; More
• Cellular location: Cytoplasm : P0A988 P0A988
• Total number of polymer chains: 2
• Total formula weight: 82146.02

Authors

Wijffels, G.,Johnson, W.M.,Oakley, A.J.,Turner, K.,Epa, V.C.,Briscoe, S.J.,Polley, M.,Liepa, A.J.,Hofmann, A.,Buchardt, J.,Christensen, C.,Prosselkov, P.,Dalrymple, B.P.,Alewood, P.F.,Jennings, P.A.,Dixon, N.E.,Winkler, D.A. (deposition date: 2011-02-20, release date: 2011-06-08, Last modification date: 2023-12-06)

• Primary citation: Wijffels, G.,Johnson, W.M.,Oakley, A.J.,Turner, K.,Epa, V.C.,Briscoe, S.J.,Polley, M.,Liepa, A.J.,Hofmann, A.,Buchardt, J.,Christensen, C.,Prosselkov, P.,Dalrymple, B.P.,Alewood, P.F.,Jennings, P.A.,Dixon, N.E.,Winkler, D.A.; Binding inhibitors of the bacterial sliding clamp by design; J.Med.Chem., 54:4831-4838, 2011; PubMed: 21604761; DOI: 10.1021/jm2004333

Experimental method

X-RAY DIFFRACTION (1.9 Å)