3QQU

Cocrystal structure of unphosphorylated igf with pyrimidine 8

Summary for 3QQU

• Entry DOI: 10.2210/pdb3qqu/pdb
• Descriptor: Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine (3 entities in total)
• Functional Keywords: igf, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P08069
• Total number of polymer chains: 4
• Total formula weight: 139107.60

Authors

Huang, X. (deposition date: 2011-02-16, release date: 2011-04-20, Last modification date: 2024-02-21)

• Primary citation: Buchanan, J.L.,Newcomb, J.R.,Carney, D.P.,Chaffee, S.C.,Chai, L.,Cupples, R.,Epstein, L.F.,Gallant, P.,Gu, Y.,Harmange, J.C.,Hodge, K.,Houk, B.E.,Huang, X.,Jona, J.,Joseph, S.,Jun, H.T.,Kumar, R.,Li, C.,Lu, J.,Menges, T.,Morrison, M.J.,Novak, P.M.,van der Plas, S.,Radinsky, R.,Rose, P.E.,Sawant, S.,Sun, J.R.,Surapaneni, S.,Turci, S.M.,Xu, K.,Yanez, E.,Zhao, H.,Zhu, X.; Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.; Bioorg.Med.Chem.Lett., 21:2394-2399, 2011; PubMed: 21414779; DOI: 10.1016/j.bmcl.2011.02.075

Experimental method

X-RAY DIFFRACTION (2.9 Å)