3QGT

Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE

Summary for 3QGT

Entry DOI	10.2210/pdb3qgt/pdb
Related	1J3I 1J3J 1J3K 3DG8 3DGA 3JSU 3QFX 3QG2 3RG9
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	malarial dhfr-ts antifolate complex, rossmann fold, reductase, dihydrofolate binding, dump binding, nadph binding, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	146260.63
Authors	Chitnumsub, P.,Yuthavong, Y. (deposition date: 2011-01-24, release date: 2011-06-29, Last modification date: 2023-11-01)
Primary citation	Vanichtanankul, J.,Taweechai, S.,Yuvaniyama, J.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y. Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6:905-911, 2011 Cited by PubMed: 21650210 DOI: 10.1021/cb200124r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation