3QFX

Trypanosoma brucei dihydrofolate reductase pyrimethamine complex

Summary for 3QFX

Entry DOI	10.2210/pdb3qfx/pdb
Related	3QG2 3QGT 3RG9
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (4 entities in total)
Functional Keywords	pyrimethamine, antifolate resistance, trypanosome, dihydrofolate reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Trypanosoma brucei rhodesiense
Total number of polymer chains	2
Total formula weight	54603.21
Authors	Vanichtanankul, J.,Yuvaniyama, J.,Taweechai, S.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y. (deposition date: 2011-01-24, release date: 2011-06-29, Last modification date: 2024-04-03)
Primary citation	Vanichtanankul, J.,Taweechai, S.,Yuvaniyama, J.,Vilaivan, T.,Chitnumsub, P.,Kamchonwongpaisan, S.,Yuthavong, Y. Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6:905-911, 2011 Cited by PubMed: 21650210 DOI: 10.1021/cb200124r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation