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3QCS

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine

Summary for 3QCS
Entry DOI10.2210/pdb3qcs/pdb
Related3NUN 3NUS 3NUU 3NUY 3QCQ 3QCX 3QCY 3QD0 3QD3 3QD4
Descriptor3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywordsagc kinase, signal transduction, atp & phosphoinositide, phosphorylation on s241, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: O15530
Total number of polymer chains1
Total formula weight36812.88
Authors
Primary citationMedina, J.R.,Becker, C.J.,Blackledge, C.W.,Duquenne, C.,Feng, Y.,Grant, S.W.,Heerding, D.,Li, W.H.,Miller, W.H.,Romeril, S.P.,Scherzer, D.,Shu, A.,Bobko, M.A.,Chadderton, A.R.,Dumble, M.,Gardiner, C.M.,Gilbert, S.,Liu, Q.,Rabindran, S.K.,Sudakin, V.,Xiang, H.,Brady, P.G.,Campobasso, N.,Ward, P.,Axten, J.M.
Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors.
J.Med.Chem., 54:1871-1895, 2011
Cited by
PubMed: 21341675
DOI: 10.1021/jm101527u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.487 Å)
Structure validation

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