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3Q7D

Structure of (R)-naproxen bound to mCOX-2.

Summary for 3Q7D
Entry DOI10.2210/pdb3q7d/pdb
DescriptorProstaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywordsprostaglandin h2 synthase, cyclooxygenase-2, naproxen, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total formula weight139661.33
Authors
Duggan, K.C.,Hermanson, D.J.,Musee, J.,Prusakiewicz, J.J.,Scheib, J.,Carter, B.D.,Banerjee, S.,Marnett, L.J. (deposition date: 2011-01-04, release date: 2011-11-09, Last modification date: 2023-09-13)
Primary citationDuggan, K.C.,Hermanson, D.J.,Musee, J.,Prusakiewicz, J.J.,Scheib, J.L.,Carter, B.D.,Banerjee, S.,Oates, J.A.,Marnett, L.J.
(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Nat.Chem.Biol., 7:803-809, 2011
Cited by
PubMed: 22053353
DOI: 10.1038/nchembio.663
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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