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3Q77

Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

Summary for 3Q77
Entry DOI10.2210/pdb3q77/pdb
Related3Q76
DescriptorNeutrophil elastase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordstrypsin family fold, protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight24556.12
Authors
Hansen, G.,Niefind, K. (deposition date: 2011-01-04, release date: 2011-05-11, Last modification date: 2023-09-13)
Primary citationHansen, G.,Gielen-Haertwig, H.,Reinemer, P.,Schomburg, D.,Harrenga, A.,Niefind, K.
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor.
J.Mol.Biol., 409:681-691, 2011
Cited by
PubMed: 21549129
DOI: 10.1016/j.jmb.2011.04.047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.998 Å)
Structure validation

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