3Q4U

Crystal structure of the ACVR1 kinase domain in complex with LDN-193189

Summary for 3Q4U

• Entry DOI: 10.2210/pdb3q4u/pdb
• Related: 3MTF 3OOM
• Descriptor: Activin receptor type-1, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: structural genomics consortium, sgc, protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771
• Total number of polymer chains: 4
• Total formula weight: 142914.61

Authors

Chaikuad, A.,Sanvitale, C.,Cooper, C.D.O.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.K.,Krojer, T.,Vollmar, M.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-12-24, release date: 2011-02-09, Last modification date: 2023-09-13)

• Primary citation: Sanvitale, C.E.,Kerr, G.,Chaikuad, A.,Ramel, M.C.,Mohedas, A.H.,Reichert, S.,Wang, Y.,Triffitt, J.T.,Cuny, G.D.,Yu, P.B.,Hill, C.S.,Bullock, A.N.; A new class of small molecule inhibitor of BMP signaling.; Plos One, 8:e62721-e62721, 2013; PubMed: 23646137; DOI: 10.1371/journal.pone.0062721

Experimental method

X-RAY DIFFRACTION (1.82 Å)