3Q4T

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin

Summary for 3Q4T

Entry DOI	10.2210/pdb3q4t/pdb
Descriptor	Activin receptor type-2A, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, SULFATE ION, ... (6 entities in total)
Functional Keywords	structural genomics consortium, sgc, protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P27037
Total number of polymer chains	2
Total formula weight	75778.41
Authors	Chaikuad, A.,Alfano, I.,Mahajan, P.,Cooper, C.D.O.,Sanvitale, C.,Vollmar, M.,Krojer, T.,Muniz, J.R.C.,Raynor, J.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-12-24, release date: 2011-02-09, Last modification date: 2023-09-13)
Primary citation	Horbelt, D.,Boergermann, J.H.,Chaikuad, A.,Alfano, I.,Williams, E.,Lukonin, I.,Timmel, T.,Bullock, A.N.,Knaus, P. Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation. J.Biol.Chem., 290:3390-3404, 2015 Cited by PubMed: 25368322 DOI: 10.1074/jbc.M114.604397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation