3Q3B
6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors
Summary for 3Q3B
| Entry DOI | 10.2210/pdb3q3b/pdb |
| Related | 1PYX 1Q3D 1Q41 1Q4L |
| Descriptor | Glycogen synthase kinase-3 beta, 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one (3 entities in total) |
| Functional Keywords | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P49841 |
| Total number of polymer chains | 2 |
| Total formula weight | 94719.56 |
| Authors | Pandit, J. (deposition date: 2010-12-21, release date: 2011-06-15, Last modification date: 2024-02-21) |
| Primary citation | Coffman, K.,Brodney, M.,Cook, J.,Lanyon, L.,Pandit, J.,Sakya, S.,Schachter, J.,Tseng-Lovering, E.,Wessel, M. 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors Bioorg.Med.Chem.Lett., 21:1429-1433, 2011 Cited by PubMed: 21295469DOI: 10.1016/j.bmcl.2011.01.017 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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