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3PWB

Bovine trypsin variant X(tripleGlu217Ile227) in complex with small molecule inhibitor

Summary for 3PWB
Entry DOI10.2210/pdb3pwb/pdb
Related1V2K 3PWC
DescriptorCationic trypsin, CALCIUM ION, BENZAMIDINE, ... (6 entities in total)
Functional Keywordstrypsin-like serine protease, hydrolase, protein binding, duodenum
Biological sourceBos taurus (bovine)
Cellular locationSecreted, extracellular space: P00760
Total number of polymer chains1
Total formula weight23766.78
Authors
Tziridis, A.,Neumann, P.,Kolenko, P.,Stubbs, M.T. (deposition date: 2010-12-08, release date: 2011-12-21, Last modification date: 2023-09-13)
Primary citationTziridis, A.,Rauh, D.,Neumann, P.,Kolenko, P.,Menzel, A.,Brauer, U.,Ursel, C.,Steinmetzer, P.,Sturzebecher, J.,Schweinitz, A.,Steinmetzer, T.,Stubbs, M.T.
Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues.
Biol.Chem., 395:891-903, 2014
Cited by
PubMed: 25003390
DOI: 10.1515/hsz-2014-0158
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

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