3PRZ

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.

Summary for 3PRZ

Entry DOI	10.2210/pdb3prz/pdb
Related	3ML8 3ML9 3OAW 3PRE 3PS6
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 4-amino-2-methyl-N-(1H-pyrazol-3-yl)quinazoline-8-carboxamide (2 entities in total)
Functional Keywords	phosphoinositide kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	110995.38
Authors	Knighton, D.R.,Greasley, S.E.,Rodgers, C.M.-L. (deposition date: 2010-11-30, release date: 2011-02-09, Last modification date: 2024-02-21)
Primary citation	Liu, K.K.,Huang, X.,Bagrodia, S.,Chen, J.H.,Greasley, S.,Cheng, H.,Sun, S.,Knighton, D.,Rodgers, C.,Rafidi, K.,Zou, A.,Xiao, J.,Yan, S. Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 21:1270-1274, 2011 Cited by PubMed: 21269826 DOI: 10.1016/j.bmcl.2010.12.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation